eagle-i University of Hawai'i ManoaUniversity of Hawai'i Manoa
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COBRE Mouse Phenotyping Core


"The Center for Cardiovascular Research provides a Mouse Phenotyping Core for the use of investigators at the University, and by special arrangement, for investigators anywhere in Hawaii. We can provide murine echocardiography, blood pressure determinations, surgical procedures and phlebotomy, as well as assistance with mouse husbandry and genotyping."(http://www2.jabsom.hawaii.edu/mousecore/)






  • Aortic banding service ( Material modification service )

    "One of the most commonly used surgical intervention for pressure-overload induced hypertrophy is coarction of the ascending aorta i.e. aortic banding. This system has been very well characterized and proven to be highly reproducible with a low mortality rate of 10-20% or less in experienced hands. Aortic banding is an excellent model system to evaluate the process of development of left ventricular hypertrophy in response to hemodynamic stress. Furthermore, after several months, a subset of animals progresses into heart failure." (http://www2.jabsom.hawaii.edu/mousecore/)

  • Blood pressure measurement service ( Analysis service )

    "Blood pressure (BP) is the pressure (force per unit area) exerted by circulating blood on the walls of blood vessels, and constitutes one of the principal vital signs. The pressure of the circulating blood decreases as it moves away from the heart through arteries and capillaries, and toward the heart through veins. When unqualified, the term blood pressure usually refers to brachial arterial pressure: that is, in the major blood vessel of the upper left or right arm that takes blood away from the heart." (http://www2.jabsom.hawaii.edu/mousecore/)

  • Cardiac output measurement service ( Analysis service )

  • Cryoablation service ( Material modification service )

  • Echocardiogram service ( Analysis service )

    "An echocardiogram, often referred to in the medical community as a cardiac ECHO or simply an ECHO, is a sonogram of the heart. Also known as a cardiac ultrasound, it uses standard ultrasound techniques to image two-dimensional slices of the heart." (http://www2.jabsom.hawaii.edu/mousecore/)

  • In vivo atherosclerosis service ( Material modification service )

    "Using one of several available mouse strains that are susceptible to atherosclerosis such as apolipoprotein E-null or low density lipoprotein receptor-null mice, studies involving the feeding of high fat and high cholesterol diet can be performed to induce atherosclerosis in mice. The appropriate tissues can be harvested at the end of the study and the extent of atherosclerosis can be quantitatively measured." (http://www2.jabsom.hawaii.edu/mousecore/)

  • Invasive hemodynamic measurement service ( Material analysis service )

  • Isolated perfused heart assay service ( Material modification service )

  • LAD ligation service ( Material modification service )

    "(LAD) ligation is a procedure to ligate the left anterior descending artery to induce an infarction. In addition, a LAD ligation can be performed as a component of ischemia-reperfusion studies, where the liagture is removed after a set period of time." (http://www2.jabsom.hawaii.edu/mousecore/)

  • Mini pump insertion service ( Material modification service )

    Applied to mice.

  • Myocardial infarction service ( Material modification service )

  • Osmotic pump implantation service ( Material modification service )

    "A pump based on a piston powered by osmotic pressure which pumps drug/s into the body over an extended period. The unit is implanted under the skin and has no external or protruding parts." (http://www2.jabsom.hawaii.edu/mousecore/)

  • Physical activity services ( Analysis service )

    "The effect of exercise on any aspect of cardiovascular function can be measured in our facility. Mice can be individually housed in cages equipped with running wheels, and wheel-running activity can be monitored continuously with a Dataquest Acquisition & Analysis System (Data Sciences International)." (http://www2.jabsom.hawaii.edu/mousecore/)

  • Pulmonary fuction testing service ( Material analysis service )

  • Small animal surgery service ( Material modification service )

  • Specialized procedure service ( Material processing service )

    If you have a procedure in mind that is not listed here (http://www2.jabsom.hawaii.edu/mousecore/), please let us know. We are well versed in many procedures that are not necessarily listed here.

  • Tail vein injection service ( Material modification service )

    "We use a catheter-based system for tail vein injections allowing for continual infusions (when used in conjunction with a pump). We also perform traditional direct syringe/needle tail vein injections used for single bolus delivery." (http://www2.jabsom.hawaii.edu/mousecore/)

  • Technician training service ( Training service )

  • Training and advice for general mouse surgery techniques ( Training service )

  • Transverse aortic constriction service ( Material modification service )

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Last updated: 2011-04-20T19:12:09.048-05:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016