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|  University of Hawai'i Manoa |
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| University of Hawai'i Manoa |
"The Center for Cardiovascular Research provides a Mouse Phenotyping Core for the use of investigators at the University, and by special arrangement, for investigators anywhere in Hawaii. We can provide murine echocardiography, blood pressure determinations, surgical procedures and phlebotomy, as well as assistance with mouse husbandry and genotyping."(http://www2.jabsom.hawaii.edu/mousecore/)
The Vevo Integrated Rail System III is a component-based apparatus that is designed to help you position an anesthetized mouse or rat in a stable position in relation to the RMV (real-time micro visualization) scanhead so you can:
• Maintain the correct image plane during an imaging session.
• Monitor and maintain the animal’s ECG, heart rate, and core body temperature.
• Manipulate the animal for image-guided injection and embryonic aspiration procedures.
With O2 flowmeter.
With Leica L6 light source.
"One of the most commonly used surgical intervention for pressure-overload induced hypertrophy is coarction of the ascending aorta i.e. aortic banding. This system has been very well characterized and proven to be highly reproducible with a low mortality rate of 10-20% or less in experienced hands. Aortic banding is an excellent model system to evaluate the process of development of left ventricular hypertrophy in response to hemodynamic stress. Furthermore, after several months, a subset of animals progresses into heart failure." (http://www2.jabsom.hawaii.edu/mousecore/)
"Blood pressure (BP) is the pressure (force per unit area) exerted by circulating blood on the walls of blood vessels, and constitutes one of the principal vital signs. The pressure of the circulating blood decreases as it moves away from the heart through arteries and capillaries, and toward the heart through veins. When unqualified, the term blood pressure usually refers to brachial arterial pressure: that is, in the major blood vessel of the upper left or right arm that takes blood away from the heart." (http://www2.jabsom.hawaii.edu/mousecore/)
"An echocardiogram, often referred to in the medical community as a cardiac ECHO or simply an ECHO, is a sonogram of the heart. Also known as a cardiac ultrasound, it uses standard ultrasound techniques to image two-dimensional slices of the heart." (http://www2.jabsom.hawaii.edu/mousecore/)
"Using one of several available mouse strains that are susceptible to atherosclerosis such as apolipoprotein E-null or low density lipoprotein receptor-null mice, studies involving the feeding of high fat and high cholesterol diet can be performed to induce atherosclerosis in mice. The appropriate tissues can be harvested at the end of the study and the extent of atherosclerosis can be quantitatively measured." (http://www2.jabsom.hawaii.edu/mousecore/)
"(LAD) ligation is a procedure to ligate the left anterior descending artery to induce an infarction. In addition, a LAD ligation can be performed as a component of ischemia-reperfusion studies, where the liagture is removed after a set period of time." (http://www2.jabsom.hawaii.edu/mousecore/)
Applied to mice.
"A pump based on a piston powered by osmotic pressure which pumps drug/s into the body over an extended period. The unit is implanted under the skin and has no external or protruding parts." (http://www2.jabsom.hawaii.edu/mousecore/)
"The effect of exercise on any aspect of cardiovascular function can be measured in our facility. Mice can be individually housed in cages equipped with running wheels, and wheel-running activity can be monitored continuously with a Dataquest Acquisition & Analysis System (Data Sciences International)." (http://www2.jabsom.hawaii.edu/mousecore/)
If you have a procedure in mind that is not listed here (http://www2.jabsom.hawaii.edu/mousecore/), please let us know. We are well versed in many procedures that are not necessarily listed here.
"We use a catheter-based system for tail vein injections allowing for continual infusions (when used in conjunction with a pump). We also perform traditional direct syringe/needle tail vein injections used for single bolus delivery." (http://www2.jabsom.hawaii.edu/mousecore/)