The Bachmann lab is located at the College of Pharmacy Department of Pharmaceutical Sciences at the University of Hawai‘i at Hilo. Research focuses primarily on a pediatric cancer called neuroblastoma. Molecular biology, cell biology and translational research is being conducted to elucidate new therapeutics and regimens for the treatment of relapsed patients with the goal to improve the currently low survival rates. Polyamine and proteasome inhibitors are investigated, and novel tumor promoting proteins (PRAF2) studied to better understand the underlying mechanisms which control tumor proliferation and metastasis. The Bachmann lab uses state-of-the-art new equipment to perform its research including the Perkin Elmer Operetta High Content Screening System with live cell capability as well as a 5 to 50 liter mammalian cell bioreactor to produce large protein quantities for downstream experimental analysis and protein crystallization. The Bachmann lab is an official member of the Neuroblastoma and Medulloblastoma Research Consortium (NMTRC) which conducts phase 1 and phase 2 clinical studies with neuroblastoma patients also using Dr. Bachmann's drug regimen. The lab also collaborates with several other U.S. and European laboratories to perform their research.
Biocommand Track & Trend and Batch Control BioProcessing software is available for use.
This system includes the image lab software.
This instrument includes a live cell chamber to maintain environmental conditions (e.g., temperature, CO2) to protect live cell samples.
It includes the following software: Harmony High Content Imaging and Analysis. Columbus Data Manager, and Velocity 3D Image Analysis software.