eagle-i University of Hawai'i ManoaUniversity of Hawai'i Manoa
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Le Saux Lab


Calcification of cardiovascular tissues occurs in a variety of pathological conditions, including vascular injury, renal failure, diabetes mellitus, atherosclerosis, and aging. Mineralization is multifactorial and results from abormal changes in the balance between activators and inhibitors of calcification. We and others have established a link between ABCC6 and the chronic calcification of pseudoxanthoma elasticum (PXE) in human and the dystrophic cardiac calcification phenotype (DCC) in mice. ABCC6 is primarily expressed in liver and the kidneys but not in connective tissues. Therefore, we use various mice models to elucidate the characteristics of this novel mineralization inhibitor pathway.





  • ABI 7300 real-time PCR system ( Real-time PCR machine )

  • ABI GeneAmp 9700 96-well PCR system ( PCR instrument )

    "GeneAmp® PCR System 9700 is specifically designed for the amplification of nucleic acids. The GeneAmp® PCR System 9700 consists of a base module and one of many interchangeable sample block modules. The 96-well GeneAmp® PCR System 9700 is designed for use with 0.2 ml reaction tubes or 96-well reaction plates for all of your routine PCR applications."

  • NanoDrop spectrophotometer ( Spectrophotometer )


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Last updated: 2013-06-14T10:59:29.077-05:00

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016