Hui Lab

Summary:

Dr. Hui's research is based on the development of blood stage malaria vaccines; and studies on the use of different vaccine adjuvants for the malaria vaccines. Specifically, his focus is on the design of vaccines based on the Merozoite Surface Protein 1 (MSP1) by defining critical T and B epitopes of the molecule. His lab also evaluates the use of a variety of immunological adjuvants to enhance vaccine potency and at the same time define the critical pathway for adjuvants’ mode of action. The approaches also study the use of nanoparticle platforms for antigen delivery.

Affiliations:

• Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine

People:

• PI: Hui, George, Ph.D.
  

Resources:

Organisms and Viruses

• Model of immunogenicity ( Mus musculus )
  

  Dr. Hui uses his animal models as a host to study the characteristics of the immune response after malaria vaccination. He uses inbred mice (1 type of response) and outbred mice (overall response) in his experiements.

Reagents

• Drosophila MSP1 antigen malaria vaccine cell line ( Immortalized embryonic cell line )
  

  Sharing subject to MTA agreement between PI's and Hawaii Biotech, Inc.

• Plasmodium falciparum MSP1 construct ( Plasmid )
  

  Vaccine construct based on Plasmodium falciparum MSP1 protein. Sharing subject to MTA agreement between PI's and Hawaii Biotech, Inc.

• Recombinant MSP1 ( Protein reagent )
  

  Sharing subject to MTA agreement between PI's and Hawaii Biotech, Inc.