Jia, Wei, Ph.D.

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1. Resource Description

   Dr. Jia has recently joined the University of Hawaii Cancer Center as the Associate Director for Shared Resources. Previously, he spent about 5 years as a Professor at University of North Carolina at Greensboro and Co-Director of UNCG Center for Translational Biomedical Research. Prior to his appointment with UNCG, Dr. Jia has worked in China for 10 years, as Professor and Executive Vice Dean at College of Pharmaceutical Science, Tianjin University, and Professor and Vice Dean, School of Pharmacy, Shanghai Jiao Tong University. Dr. Jia’s research interest involves defining the molecular mechanisms that link metabolic disruptions in gut microbial-host co-metabolism to metabolic disorders and gastrointestinal cancer. Several research projects are being conducted in Dr. Jia’s group to decipher the complex metabolic interactions in gut-liver-brain axis and understand the metabolic defects associated with gastrointestinal carcinogenesis. In addition, Dr. Jia directs a well-recognized metabolomics laboratory (currently as one of the UHCC shared resources). Over the past 10 years, his lab has developed a number of metabolomics technologies and protocols, focusing on the quantitative analysis of endogenous small-molecule metabolites and trace elements from biological specimens including blood, urine, saliva, and tissues of experimental animals and human subjects. Many of these technologies have been applied in clinical and translational research, involving (1) unbiased metabolic profiling and data mining, metabolite annotation and biological interpretation using combined high sensitivity, high throughput LC-MS-MS and GC-MS platforms; (2) targeted and quantitative analysis of metabolic flux and pathways using isotope labeled metabolites and a LC-triple quatrupole mass spectrometry platform; (3) classification and prediction of disease phenotypes based on their unique metabolic signatures and biomarkers for patient stratification and personalized treatment; and (4) methodologies using metabolomics approach to delineate the gut microbial-host co-metabolism of multi-component agents, such as plant-derived polyphenols and herbal medicine, as well as their metabolic impact on human health.

2. First Name

   Wei

3. Last Name

   Jia

4. Title

   Assistant Director of Shared Resources

5. Website(s)

   http://www.uhcancercenter.org/about-us/directory/faculty-staff/2-directory/285