Phase III study of postoperative radiation therapy (IMRT) +/- cetuximab for locally-advanced resected head and neck cancer

eagle-i ID

Resource Type

Properties

1. ClinicalTrials.gov url

   http://www.clinicaltrials.gov/ct2/show/NCT00956007?term=RTOG-0920&rank=2

2. Intervention

   Intensity-modulated radiation therapy

3. Intervention

   Cetuximab

4. Resource Description

   Giving radiation therapy that uses a 3-dimensional (3-D) image of the tumor to help focus thin beams of radiation directly on the tumor, and giving radiation therapy in higher doses over a shorter period of time, may kill more tumor cells and have fewer side effects. Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. This randomized phase III trial is studying radiation therapy to see how well it works compared with radiation therapy given together with cetuximab in treating patients who have undergone surgery for locally advanced head and neck cancer.

5. Contact

   Berenberg, Jeffrey

6. PI

   Berenberg, Jeffrey

7. Topic

   head and neck cancer

8. Topic

   squamous cell carcinoma

9. Topic

   verrucous carcinoma

10. Study Population

    Males and females 18 years old and older with histologically confirmed squamous cell carcinoma (including variants, such as verrucous carcinoma, spindle cell carcinoma, or carcinoma not otherwise specified) of the head and neck.

11. Website(s)

    http://www.cancer.gov/clinicaltrials/search/view?cdrid=651536&version=healthprofessional

12. Funded by

    Radiation Therapy Oncology Group

13. Phase

    Phase 3 clinical trial

14. Performed by

    Clinical Protocol & Data Management Shared Resource