Randomized, phase II, double-blind, placebo-controlled trial of conventional chemoradiation and adjuvant temozolomide plus cediranib versus conventional chemoradiation and adjuvant temozolomide plus placebo in patients with newly diagnosed glioblastoma

eagle-i ID

Resource Type

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1. ClinicalTrials.gov url

   http://www.clinicaltrials.gov/ct2/show/NCT01062425?term=RTOG-0837&rank=1

2. Intervention

   Cediranib maleate

3. Intervention

   Temozolomide

4. Intervention

   Radiation therapy

5. Intervention

   Trastuzumab

6. Additional Topic(s)

   Antineoplastic combined chemotherapy protocols

7. Resource Description

   PURPOSE: This randomized phase II trial is studying temozolomide, radiation therapy, and cediranib maleate to see how well they work compared with temozolomide, radiation therapy, and a placebo in treating patients with newly diagnosed glioblastoma.

8. Contact

   Berenberg, Jeffrey

9. PI

   Berenberg, Jeffrey

10. Topic

    brain cancer

11. Study Population

    Males and females age 18 and older with histologically confirmed glioblastoma or gliosarcoma (WHO grade IV).

12. Website(s)

    http://www.cancer.gov/clinicaltrials/search/view?cdrid=665163&version=healthprofessional

13. Funded by

    Radiation Therapy Oncology Group

14. Phase

    Phase 2 clinical trial

15. Performed by

    Clinical Protocol & Data Management Shared Resource