Phase III prospective randomized trial of dose-escalated radiotherapy with or without short-term androgen deprivation therapy for patients with intermediate-risk prostate cancer

eagle-i ID

Resource Type

Properties

1. ClinicalTrials.gov url

   http://www.clinicaltrials.gov/ct2/show/NCT00936390?term=RTOG-0815&rank=1

2. Intervention

   Adjuvant radiotherapy

3. Intervention

   EBRT

4. Intervention

   External-beam radiation therapy

5. Intervention

   Androgen-deprivation therapy

6. Intervention

   Androgen antagonists

7. Intervention

   Antineoplastic agents, hormonal

8. Resource Description

   RATIONALE: Radiation therapy uses high-energy x-rays and other types of radiation to kill tumor cells and shrink tumors. Androgens can cause the growth of prostate cancer cells. Androgen-deprivation therapy may lessen the amount of androgens made by the body. It is not yet known whether radiation therapy is more effective with or without androgen-deprivation therapy in treating patients with prostate cancer. PURPOSE: This randomized phase III trial is studying radiation therapy to see how well it works compared with radiation therapy given together with androgen-deprivation therapy in treating patients with prostate cancer.

9. Contact

   Berenberg, Jeffrey

10. PI

    Berenberg, Jeffrey

11. Topic

    prostate cancer

12. Study Population

    Males aged 18 and older with histologically confirmed adenocarcinoma of the prostate diagnosed within the past 6 months and at intermediate-risk for recurrence.

13. Website(s)

    http://www.cancer.gov/clinicaltrials/search/view?cdrid=648194&version=healthprofessional

14. Phase

    Phase 3 clinical trial

15. Performed by

    Clinical Protocol & Data Management Shared Resource