Radiation therapy and either capecitabine or fluorouracil with or without oxaliplatin before surgery in treating patients with resectable rectal cancer

eagle-i ID

Resource Type

Properties

1. ClinicalTrials.gov url

   http://www.clinicaltrials.gov/ct2/show/NCT00058474?term=NSABP-R-04&rank=1

2. Intervention

   Radiation therapy

3. Intervention

   Capecitabine

4. Intervention

   Flourouracil

5. Intervention

   Oxaliplatin

6. Resource Description

   RATIONALE: Drugs used in chemotherapy, such as capecitabine, fluorouracil, and oxaliplatin work in different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. PURPOSE: This randomized phase III trial is studying radiation therapy and either capecitabine or fluorouracil with or without oxaliplatin and comparing them to see how well they work when given before surgery in treating patients with resectable rectal cancer. It is not yet known whether radiation therapy and either capecitabine or fluorouracil is more effective with or without oxaliplatin in treating rectal cancer.

7. Additional Name

   Clinical trial comparing preoperative radiation therapy and capecitabine with or without oxaliplatin with preoperative radiation therapy and continuous intravenous infusion Of 5-fluorouracil with or without oxaliplatin in the treatment of patients with operable carcinoma of the rectum

8. Contact

   Berenberg, Jeffrey

9. PI

   Berenberg, Jeffrey

10. Topic

    rectum cancer

11. Study Population

    Men and women 18 years and older with a diagnosis of adenocarcinoma of the rectum and meeting other eligibility requirements

12. Funded by

    National Surgical Adjuvant Breast and Bowel Project

13. Phase

    Phase 3 clinical trial

14. Performed by

    Clinical Protocol & Data Management Shared Resource