The use of glutathione (GSH) for prevention of paclitaxel/carboplatin (TAXOL/CBDCA) induced peripheral neuropathy: a phase III randomized, double-blind placebo controlled study

eagle-i ID

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1. ClinicalTrials.gov url

   http://www.clinicaltrials.gov/ct2/show/NCT00979082?term=N08CA&rank=1

2. Intervention

   Carboplatin

3. Intervention

   Glutathione

4. Intervention

   Paclitaxel

5. Additional Topic(s)

   Antineoplastic combined chemotherapy protocols

6. Resource Description

   Chemoprotective drugs, such as glutathione, may help prevent peripheral neuropathy caused by paclitaxel and carboplatin. It is not yet known whether glutathione is more effective than a placebo in preventing peripheral neuropathy. This randomized phase III trial is studying glutathione to see how well it works in preventing peripheral neuropathy caused by paclitaxel and carboplatin in patients with ovarian cancer, fallopian tube cancer, and/or primary peritoneal cancer.

7. Contact

   Berenberg, Jeffrey

8. PI

   Berenberg, Jeffrey

9. Topic

   ovarian cancer

10. Study Population

    Study participants must be females who are 18 years and older.

11. Funded by

    North Central Cancer Treatment Group

12. Phase

    Phase 3 clinical trial

13. Performed by

    Clinical Protocol & Data Management Shared Resource