Phase III trial of pelvic radiation therapy versus vaginal cuff brachytherapy followed by paclitaxel/carboplatin chemotherapy in patients with high risk, early stage endometrial carcinoma

eagle-i ID

Resource Type

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1. ClinicalTrials.gov url

   http://www.clinicaltrials.gov/ct2/show/NCT00807768?term=GOG-0249&rank=1

2. Intervention

   Carboplatin

3. Intervention

   Radiation therapy

4. Intervention

   Paclitaxel

5. Intervention

   Brachytherapy

6. Resource Description

   This randomized phase III trial is studying pelvic radiation therapy to see how well it works compared with vaginal implant radiation therapy, paclitaxel, and carboplatin in treating patients with high-risk stage I or stage II endometrial cancer.

7. Contact

   Berenberg, Jeffrey

8. PI

   Berenberg, Jeffrey

9. Topic

   endometrial cancer

10. Study Population

    Females at least 18 years old with no more than 12 weeks since undergoing surgery to remove the uterus, ovaries, and fallopian tubes, no stage III, stage IV, or recurrent cancer, no sarcoma, carcinosarcoma, or leiomyosarcoma of the uterus, no previous chemotherapy, radiation therapy, hormone therapy, or biological therapy for endometrial cancer, and no previous chemotherapy or radiation therapy for any other cancer.

11. Website(s)

    http://www.cancer.gov/clinicaltrials/featured/trials/gog-0249

12. Website(s)

    http://www.cancer.gov/clinicaltrials/search/view?cdrid=629591&version=healthprofessional

13. Funded by

    Gynecologic Oncology Group

14. Performed by

    Clinical Protocol & Data Management Shared Resource