eagle-i University of Hawaii at ManoaUniversity of Hawaii at Manoa
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Risk-based treatment for pediatric non-rhabdomyosarcoma soft tissue sarcomas (NRSTS)

eagle-i ID


Resource Type

  1. Clinical trial


  1. Additional Topic(s)
    Antineoplastic combined chemotherapy protocols
  2. Additional Topic(s)
  3. Resource Description
    Studies done in both children and adults with Non-rhabdomyosarcoma soft tissue sarcomas have shown that the amount of treatment a patient needs may be based on the “risk group” of the tumor. Tumors are assigned a risk group based on features that influence how they behave. For NRSTS, the risk group is based on the type of cells in the tumor (the grade of the tumor), the size of the tumor, if the tumor has spread to other areas of the body, and how much of the tumor can be taken out by surgery. Patients with tumors in the low risk group may be cured with mild treatment, in some cases only surgery. Patients with tumors in the intermediate and high-risk groups may need more treatment, including anti-cancer drugs (chemotherapy) and high energy X-ray therapy (radiation therapy). This study is being done to find out: if treatment based on each subject's level of risk will get rid of the tumor and if lessening the treatment for lower risk subjects will decrease the side effects of treatment and still get rid of the tumor.
  4. Contact
    Berenberg, Jeffrey
  5. PI
    Wilkinson, Robert, M.D.
  6. Topic
    connective tissue cancer
  7. Study Population
    This study is for patients less than 30 years of age at the time of the biopsy that established the diagnosis of NRSTS. Patients < 2 years of age with infantile fibrosarcoma are not eligible for this study. There must be a diagnosis of NRSTS that is confirmed by COG designated pathologists.
  8. Website(s)
  9. Funded by
    Children's Oncology Group
  10. Phase
    Phase 3 clinical trial
  11. Performed by
    Clinical Protocol & Data Management Shared Resource
Provenance Metadata About This Resource Record
Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016