Treatment of newly diagnosed higher risk favorable histology Wilms tumor

eagle-i ID

Resource Type

Properties

1. Intervention

   Radiation therapy

2. Intervention

   Antineoplastic combined chemotherapy

3. Additional Topic(s)

   Antineoplastic Combined Chemotherapy Protocols

4. Additional Topic(s)

   Radiotherapy

5. Resource Description

   The overall goal of this study is to find out: if subjects with Wilms tumor that has spread only to their lungs can be treated without having radiation therapy to their lungs. Subjects whose lung tumors go away completely after the first six weeks of standard chemotherapy will not have to have radiation therapy if subjects with Wilms tumor that has spread only to their lungs whose lung tumors do not go away after the first six weeks of standard chemotherapy for Wilms tumor can be treated by using two additional chemotherapy drugs, plus radiation therapy if subjects who have Wilms tumor that has spread to other parts of the body in addition to or instead of in the lungs, can be treated by using two additional chemotherapy drugs along with the standard drugs, and radiation therapy if some genetic information about the tumor cells can help us put subjects in the experimental treatment group.

6. Contact

   Berenberg, Jeffrey

7. PI

   Wilkinson, Robert, M.D.

8. Topic

   nephroblastoma

9. Study Population

   Patients must be < 30 years of age and must meet certain other disease-related criteria.

10. Website(s)

    http://www.curesearch.org/ArticleView2.aspx?id=9109&l=8673

11. Funded by

    Children's Oncology Group

12. Phase

    Phase 3 clinical trial

13. Performed by

    Clinical Protocol & Data Management Shared Resource