Treatment of childhood nasopharyngeal carcinoma with neoadjuvant chemotherapy and concomitant chemoradiotherapy

eagle-i ID

Resource Type

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1. ClinicalTrials.gov url

   http://www.clinicaltrials.gov/ct2/show/NCT00274937?term=Treatment+of+Childhood+Nasopharyngeal+Carcinoma+with+Neoadjuvant+Chemotherapy+and+Concomitant+Chemoradiotherapy&rank=1

2. Intervention

   Amifostine

3. Intervention

   Cisplatin

4. Intervention

   Fluorouracil

5. Intervention

   Radiation therapy

6. Additional Topic(s)

   Antineoplastic combined chemotherapy protocols

7. Additional Topic(s)

   Radiotherapy

8. Resource Description

   Recent studies done in adults with an NPC-type tumor have shown that chemoradiotherapy works better than radiation therapy followed by chemotherapy. Studies in adults have also shown that the drug amifostine can help prevent the loss of, and thickening of, saliva. This side effect of radiation therapy to the head and neck causes dryness of the mouth which leads to dental problems, problems swallowing and infections. This study will use radiation therapy, chemotherapy and chemoradiotherapy. The goals of this study are: To see if a combination of chemotherapy followed by chemoradiotherapy works better at treating children with advanced NPC than the standard therapy used in adults, which is chemoradiotherapy only. To see how well amifostine protects children against dry mouth when given daily before radiation therapy.

9. Contact

   Berenberg, Jeffrey

10. PI

    Wilkinson, Robert, M.D.

11. Topic

    nasopharyngeal disease

12. Study Population

    Patients are less than 19 years of age at the time of diagnosis with newly diagnosed nasopharyngeal carcinoma (NPC) WHO Type II or III. They have had no prior treatment for the NPC.

13. Website(s)

    http://www.curesearch.org/ArticleView2.aspx?id=9106&l=8673

14. Funded by

    Children's Oncology Group

15. Phase

    Phase 3 clinical trial

16. Performed by

    Clinical Protocol & Data Management Shared Resource