eagle-i University of Hawaii at ManoaUniversity of Hawaii at Manoa
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Treatment of childhood nasopharyngeal carcinoma with neoadjuvant chemotherapy and concomitant chemoradiotherapy

eagle-i ID


Resource Type

  1. Clinical trial


  1. ClinicalTrials.gov url
  2. Intervention
  3. Intervention
  4. Intervention
  5. Intervention
    Radiation therapy
  6. Additional Topic(s)
    Antineoplastic combined chemotherapy protocols
  7. Additional Topic(s)
  8. Resource Description
    Recent studies done in adults with an NPC-type tumor have shown that chemoradiotherapy works better than radiation therapy followed by chemotherapy. Studies in adults have also shown that the drug amifostine can help prevent the loss of, and thickening of, saliva. This side effect of radiation therapy to the head and neck causes dryness of the mouth which leads to dental problems, problems swallowing and infections. This study will use radiation therapy, chemotherapy and chemoradiotherapy. The goals of this study are: To see if a combination of chemotherapy followed by chemoradiotherapy works better at treating children with advanced NPC than the standard therapy used in adults, which is chemoradiotherapy only. To see how well amifostine protects children against dry mouth when given daily before radiation therapy.
  9. Contact
    Berenberg, Jeffrey
  10. PI
    Wilkinson, Robert, M.D.
  11. Topic
    nasopharyngeal disease
  12. Study Population
    Patients are less than 19 years of age at the time of diagnosis with newly diagnosed nasopharyngeal carcinoma (NPC) WHO Type II or III. They have had no prior treatment for the NPC.
  13. Website(s)
  14. Funded by
    Children's Oncology Group
  15. Phase
    Phase 3 clinical trial
  16. Performed by
    Clinical Protocol & Data Management Shared Resource
Provenance Metadata About This Resource Record
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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016