Treatment of children with newly-diagnosed low stage lymphocyte predominant Hodgkin disease (LPHD)

eagle-i ID

Resource Type

Properties

1. Intervention

   Radiation therapy

2. Intervention

   Chemotherapy

3. Additional Topic(s)

   Drug dosage

4. Resource Description

   One specific type of Hodgkin disease is known as Lymphocyte Predominant Hodgkin Disease (LPHD). The standard treatment for Hodgkin disease is chemotherapy and radiation therapy (high-dose x-rays). Most patients are cured of their Hodgkin disease, but some people have side effects from the therapy later in life. These kinds of side effects are often called “late effects.” Late effects can include problems with growth, organ function, and sometimes a second kind of cancer. Late effects may be caused by either chemotherapy or radiation. Researchers believe that if some people can be treated with less therapy or with surgery alone, then these people might have fewer late effects. The goals of this study are to see if late effects can be lessened or prevented by using less chemotherapy and radiation. Another goal is to find out if using less chemotherapy and radiation to treat LPHD will still show high cure rates. Some subjects (people participating in the study) will get no chemotherapy or radiation if only one lymph node was affected by LPHD and a surgeon completely removed it.

5. Contact

   Berenberg, Jeffrey

6. PI

   Wilkinson, Robert, M.D.

7. Topic

   Hodgkin's lymphoma

8. Study Population

   This study is for patients with low stage (Stage I or II), newly diagnosed Hodgkin Disease that is classified as “lymphocyte predominant” type that has not been treated with chemotherapy or radiation therapy. Patients between the ages of 0 to 21 years old are eligible.

9. Website(s)

   http://www.curesearch.org/ArticleView2.aspx?id=7346&l=8673

10. Funded by

    Children's Oncology Group

11. Phase

    Phase 0 clinical trial

12. Performed by

    Clinical Protocol & Data Management Shared Resource