eagle-i University of Hawaii at ManoaUniversity of Hawaii at Manoa
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Treatment of children with newly-diagnosed low stage lymphocyte predominant Hodgkin disease (LPHD)

eagle-i ID


Resource Type

  1. Clinical trial


  1. Intervention
    Radiation therapy
  2. Intervention
  3. Additional Topic(s)
    Drug dosage
  4. Resource Description
    One specific type of Hodgkin disease is known as Lymphocyte Predominant Hodgkin Disease (LPHD). The standard treatment for Hodgkin disease is chemotherapy and radiation therapy (high-dose x-rays). Most patients are cured of their Hodgkin disease, but some people have side effects from the therapy later in life. These kinds of side effects are often called “late effects.” Late effects can include problems with growth, organ function, and sometimes a second kind of cancer. Late effects may be caused by either chemotherapy or radiation. Researchers believe that if some people can be treated with less therapy or with surgery alone, then these people might have fewer late effects. The goals of this study are to see if late effects can be lessened or prevented by using less chemotherapy and radiation. Another goal is to find out if using less chemotherapy and radiation to treat LPHD will still show high cure rates. Some subjects (people participating in the study) will get no chemotherapy or radiation if only one lymph node was affected by LPHD and a surgeon completely removed it.
  5. Contact
    Berenberg, Jeffrey
  6. PI
    Wilkinson, Robert, M.D.
  7. Topic
    Hodgkin's lymphoma
  8. Study Population
    This study is for patients with low stage (Stage I or II), newly diagnosed Hodgkin Disease that is classified as “lymphocyte predominant” type that has not been treated with chemotherapy or radiation therapy. Patients between the ages of 0 to 21 years old are eligible.
  9. Website(s)
  10. Funded by
    Children's Oncology Group
  11. Phase
    Phase 0 clinical trial
  12. Performed by
    Clinical Protocol & Data Management Shared Resource
Provenance Metadata About This Resource Record
Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016