eagle-i University of Hawaii at ManoaUniversity of Hawaii at Manoa
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Efficacy of carboplatin administered concomitantly with radiation and isotretinoin as a pro-apoptotic agent in other than average risk medulloblastoma/PNET patients

eagle-i ID


Resource Type

  1. Clinical trial


  1. Intervention
  2. Intervention
  3. Additional Topic(s)
    Adjuvant chemotherapy
  4. Additional Topic(s)
    Antineoplastic combined chemotherapy
  5. Resource Description
    The overall goal of this study is to compare the effects, good and/or bad, of the chemotherapy drugs carboplatin and isotretinoin on subjects with high risk medulloblastoma and to find out if one or both are better than standard therapy alone. The purpose of this study is: To find out if giving the drug carboplatin along with radiation therapy is more effective than giving radiation therapy alone. To find out if the drug isotretinoin can improve the survival of subjects with high risk medulloblastoma. To measure any effects that the different types of treatment have on the quality of life (general well-being). To measure the brain function of subjects (measuring intelligence, memory, language, nonverbal skills, attention, and academic achievement) and the relationship between level of brain function and their quality of life. Another purpose of the study which is optional is: To identify markers in the DNA of tumor tissue that will help us know how best to treat patients in the future and to pick the most promising new therapies for future studies.
  6. Contact
    Berenberg, Jeffrey
  7. PI
    Wilkinson, Robert, M.D.
  8. Topic
  9. Study Population
    People 3 to 21 years of age at diagnosis
  10. Website(s)
  11. Funded by
    Children's Oncology Group
  12. Phase
    Phase 3 clinical trial
  13. Performed by
    Clinical Protocol & Data Management Shared Resource
Provenance Metadata About This Resource Record
  1. workflow state
  2. contributor
  3. created
  4. creator
    awendicke (Annemarie Wendicke)
  5. modified
Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016