Efficacy of carboplatin administered concomitantly with radiation and isotretinoin as a pro-apoptotic agent in other than average risk medulloblastoma/PNET patients

eagle-i ID

Resource Type

Properties

1. Intervention

   Carboplatin

2. Intervention

   Isotretinoin

3. Additional Topic(s)

   Adjuvant chemotherapy

4. Additional Topic(s)

   Antineoplastic combined chemotherapy

5. Resource Description

   The overall goal of this study is to compare the effects, good and/or bad, of the chemotherapy drugs carboplatin and isotretinoin on subjects with high risk medulloblastoma and to find out if one or both are better than standard therapy alone. The purpose of this study is: To find out if giving the drug carboplatin along with radiation therapy is more effective than giving radiation therapy alone. To find out if the drug isotretinoin can improve the survival of subjects with high risk medulloblastoma. To measure any effects that the different types of treatment have on the quality of life (general well-being). To measure the brain function of subjects (measuring intelligence, memory, language, nonverbal skills, attention, and academic achievement) and the relationship between level of brain function and their quality of life. Another purpose of the study which is optional is: To identify markers in the DNA of tumor tissue that will help us know how best to treat patients in the future and to pick the most promising new therapies for future studies.

6. Contact

   Berenberg, Jeffrey

7. PI

   Wilkinson, Robert, M.D.

8. Topic

   medulloblastoma

9. Study Population

   People 3 to 21 years of age at diagnosis

10. Website(s)

    http://www.curesearch.org/ArticleView2.aspx?id=7336&l=8673

11. Funded by

    Children's Oncology Group

12. Phase

    Phase 3 clinical trial

13. Performed by

    Clinical Protocol & Data Management Shared Resource