eagle-i University of Hawaii at ManoaUniversity of Hawaii at Manoa
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Study evaluating limited target volume boost irradiation and reduced dose craniospinal radiotherapy (18.00 Gy) and chemotherapy in children with newly diagnosed standard risk medulloblastoma: a phase III double randomized trial

eagle-i ID


Resource Type

  1. Clinical trial


  1. ClinicalTrials.gov url
  2. Intervention
  3. Intervention
  4. Intervention
  5. Intervention
    Vincristine sulfate
  6. Intervention
    Radiation therapy
  7. Additional Topic(s)
    Antineoplastic combined chemotherapy protocols
  8. Additional Topic(s)
  9. Resource Description
    The purpose of this study is to find out if the overall dose of radiation to the brain and spine can be reduced without decreasing the survival rates. The study will also look at whether the volume of radiation given during the “boost” to the specific area of the tumor can safely be reduced without decreasing survival. Additional goals of this study are to: To identify whether children who receive less radiation and have their tumors come back share similar characteristics. To reduce the effects of radiation on the child’s hearing, ability to learn, and hormone function. To look at whether children who receive lower doses of radiation have fewer long-term side effects of treatment. To perform studies on removed tumor in the laboratory that may predict prognosis.
  10. Contact
    Berenberg, Jeffrey
  11. PI
    Wilkinson, Robert, M.D.
  12. Topic
  13. Study Population
    Males and females between the ages of 3 and 21 at the time of diagnosis with histologically confirmed medulloblastoma located in the posterior fossa.
  14. Website(s)
  15. Website(s)
  16. Funded by
    Children's Oncology Group
  17. Phase
    Phase 3 clinical trial
  18. Performed by
    Clinical Protocol & Data Management Shared Resource
Provenance Metadata About This Resource Record
Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016