Study of conformal radiotherapy in patients with low-grade gliomas

eagle-i ID

Resource Type

Properties

1. Intervention

   Small-field radiation therapy

2. Resource Description

   Older children with low grade gliomas that have come back after surgery or are causing problems are often treated with radiation therapy. Younger children are usually treated first with chemotherapy, but if the tumor comes back following completion of therapy, then they often receive radiation therapy as well. Radiation therapy can cause severe side effects. New types of radiation therapy can treat a smaller area of the brain and doctors think that patients who receive this type of radiation might have fewer side effects. The purpose of this study is to test the safety and effectiveness of this “smaller field radiation” in patients with low grade gliomas. This study will also try to determine if the results of a special test performed on the removed tumor tissue predict how the tumor may respond to radiation. Finally, this study will also evaluate the functional status and quality-of-life of children with low grade gliomas who receive this treatment.

3. Contact

   Berenberg, Jeffrey

4. PI

   Wilkinson, Robert, M.D.

5. Topic

   malignant glioma

6. Study Population

   Patients enrolled on this study must be > 3 years and < 21 years at the time of diagnosis.

7. Website(s)

   http://www.curesearch.org/ArticleView2.aspx?id=7328&l=8673

8. Funded by

   Children's Oncology Group

9. Phase

   Phase 2 clinical trial

10. Performed by

    Clinical Protocol & Data Management Shared Resource