eagle-i University of Hawaii at ManoaUniversity of Hawaii at Manoa
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Randomized Phase III Study of Sodium Thiosulfate for the Prevention of Cisplatin-Induced Ototoxicity in Children

eagle-i ID


Resource Type

  1. Clinical trial


  1. ClinicalTrials.gov url
  2. Intervention
    Sodium thiosulfate
  3. Intervention
  4. Additional Topic(s)
  5. Resource Description
    Cisplatin is a chemotherapy medicine that is used for many types of childhood cancer. Cisplatin can cause side effects to the blood and kidney systems. Cisplatin may also cause a side effect called ototoxicity. Ototoxicity is damage to the hearing system that causes hearing loss or ringing in the ears (tinnitus). This hearing loss can be permanent. Sodium thiosulfate (STS) is a medicine that may prevent this kind of hearing loss. The goal of this research study is to evaluate if STS can prevent hearing loss in participants receiving cisplatin chemotherapy for newly diagnosed cancers.
  6. Additional Name
    Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy
  7. Contact
    Berenberg, Jeffrey
  8. PI
    Wilkinson, Robert, M.D.
  9. Topic
  10. Topic
    brain cancer
  11. Topic
    ovarian cancer
  12. Topic
    germ cell and embryonal cancer
  13. Topic
    liver cancer
  14. Topic
    central nervous system cancer
  15. Topic
  16. Study Population
    Patients must 1 year of age or older, but younger than 19 years old.
  17. Funded by
    Children's Oncology Group
  18. Phase
    Phase 3 clinical trial
  19. Performed by
    Clinical Protocol & Data Management Shared Resource
Provenance Metadata About This Resource Record
Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016