eagle-i University of Hawaii at ManoaUniversity of Hawaii at Manoa
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Intensified Tyrosine Kinase Inhibitor Therapy (Dasatinib: IND# 73969, NSC# 732517) in Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia

eagle-i ID


Resource Type

  1. Clinical trial


  1. ClinicalTrials.gov url
  2. Intervention
  3. Intervention
  4. Intervention
  5. Intervention
  6. Intervention
    Daunorubicin hydrochloride
  7. Intervention
  8. Intervention
  9. Intervention
  10. Intervention
    Leucovorin calcium
  11. Intervention
  12. Intervention
  13. Intervention
  14. Intervention
  15. Intervention
  16. Intervention
    Therapeutic hydrocortisone
  17. Intervention
    Vincristine sulfate
  18. Resource Description
    "The goals of AALL0622 are to assess the safety and feasibility of substituting dasatinib for imatinib in the high-risk ALL protocol chemotherapy backbone, to determine whether intensive chemotherapy plus dasatinib will lead to a 3-year event free survival of at least 60% in patients with Ph+ALL and a good early response to therapy, to assess the effect of these changes on levels of MRD present at end of Induction and end of Consolidation Block 2 compared to AALL0031 and to measure the 3-year EFS for all patients (Standard and High-Risk) receiving dasatinib."
  19. Additional Name
    Dasatinib and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
  20. Contact
    Berenberg, Jeffrey
  21. PI
    Wilkinson, Robert, M.D.
  22. Topic
    lymphoid leukemia
  23. Study Population
    Patients must be newly diagnosed, 1 to 30 years of age at time of diagnosis, be enrolled in certain other Children's Oncology Group trials, and meet other therapeutic criteria.
  24. Funded by
    Children's Oncology Group
  25. Phase
    Phase 3 clinical trial
  26. Performed by
    Clinical Protocol & Data Management Shared Resource
Provenance Metadata About This Resource Record
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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016