Intensified Tyrosine Kinase Inhibitor Therapy (Dasatinib: IND# 73969, NSC# 732517) in Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia

eagle-i ID

Resource Type

Properties

1. ClinicalTrials.gov url

   http://www.clinicaltrial.gov/ct2/show/NCT00720109

2. Intervention

   Asparaginase

3. Intervention

   Cyclophosphamide

4. Intervention

   Cytarabine

5. Intervention

   Dasatinib

6. Intervention

   Daunorubicin hydrochloride

7. Intervention

   Dexamethasone

8. Intervention

   Etoposide

9. Intervention

   Ifosfamide

10. Intervention

    Leucovorin calcium

11. Intervention

    Mercaptopurine

12. Intervention

    Methotrexate

13. Intervention

    Methylprednisolone

14. Intervention

    Pegaspargase

15. Intervention

    Prednisone

16. Intervention

    Therapeutic hydrocortisone

17. Intervention

    Vincristine sulfate

18. Resource Description

    "The goals of AALL0622 are to assess the safety and feasibility of substituting dasatinib for imatinib in the high-risk ALL protocol chemotherapy backbone, to determine whether intensive chemotherapy plus dasatinib will lead to a 3-year event free survival of at least 60% in patients with Ph+ALL and a good early response to therapy, to assess the effect of these changes on levels of MRD present at end of Induction and end of Consolidation Block 2 compared to AALL0031 and to measure the 3-year EFS for all patients (Standard and High-Risk) receiving dasatinib."

19. Additional Name

    Dasatinib and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

20. Contact

    Berenberg, Jeffrey

21. PI

    Wilkinson, Robert, M.D.

22. Topic

    lymphoid leukemia

23. Study Population

    Patients must be newly diagnosed, 1 to 30 years of age at time of diagnosis, be enrolled in certain other Children's Oncology Group trials, and meet other therapeutic criteria.

24. Funded by

    Children's Oncology Group

25. Phase

    Phase 3 clinical trial

26. Performed by

    Clinical Protocol & Data Management Shared Resource