eagle-i University of Hawaii at ManoaUniversity of Hawaii at Manoa
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Licensing for Taccalonolide A (microtubule-stabilizing agent)

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Resource Type

  1. Access service


  1. Resource Description
    "This new microtubule-stabilizing agent is an effective cytotoxin against many cancer cells in vitro. Bioassay-directed purification of the crude lipophilic extract yielded a steroid with paclitaxel-like microtubule-stabilizing activity. Non-transformed cells treated with the agent exhibited interphase arrest and extensive microtubule bundling. Many of the microtubule bundles were located in the cell periphery, apparently nucleated independent of the microtubule-organizing center. The compound also initiated the breakdown of the nucleus into micronuclei."
  2. Contact
    Taylor, Lee
  3. Service Provided by
    Office of Technology Transfer and Economic Development (OTTED)
  4. Website(s)
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Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016