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Licensing for Taccalonolide A (microtubule-stabilizing agent)

http://hawaii.eagle-i.net/i/00000130-2895-49d6-cec9-714480000000

Resource Description

"This new microtubule-stabilizing agent is an effective cytotoxin against many cancer cells in vitro. Bioassay-directed purification of the crude lipophilic extract yielded a steroid with paclitaxel-like microtubule-stabilizing activity. Non-transformed cells treated with the agent exhibited interphase arrest and extensive microtubule bundling. Many of the microtubule bundles were located in the cell periphery, apparently nucleated independent of the microtubule-organizing center. The compound also initiated the breakdown of the nucleus into micronuclei."
Contact

Taylor, Lee
Service Provided by

Office of Technology Transfer and Economic Development (OTTED)
Website(s)

http://www.otted.hawaii.edu/technology/00219/discovery-new-microtubule-stabilizing-agent-named-taccalonolide

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