eagle-i University of Hawaii at ManoaUniversity of Hawaii at Manoa
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Licensing for biochemical sensing method and device

eagle-i ID


Resource Type

  1. Access service


  1. Resource Description
    "Medical diagnostics using chemical sensing of antibody, antigens, DNA fragments and other biochemicals are addressed using semiconductor sensors and supportive biochemical processes. This successful marriage of semiconductor sensors and biochemistry address a diversity of potential biochemical diagnostics and measurements including detection and quantification of human, animal and plant diseases. Target biochemical molecules attach specifically to one or more preselected, sensor-attached biochemical receptors resulting in a concentration- related, large output electronic output signal (current or voltage). This innovation overcomes low sensitivity and drift problems associated with earlier semiconductor biochemical sensing. Prototype devices have been developed and successfully tested. Experiments have shown high sensitivity and high specificity biochemical detection with very large electronic outputs measured. Multiple target detection and senor arrays with enhanced signal amplification and automation are enabled in this silicon IC technology. The basic operating principle of the biochemical sensor is to detect target molecules of a specific chemical compound by placing a liquid substrate (containing the target molecules) in contact with receptor-coated semiconductor sensor devices. Biochemical detection uses specific device architectures and processes. Typical large voltage or current output signals, proportional to the receptor-bound specific biochemical molecule density and its electric charges, are measured. Add-on amplifier devices can further enhance the already high detection sensitivity. Sensor devices may be prepared to simultaneously detect multiple specific biochemical species. Sensor device arrays may be constructed to provide multiple detection means in a single low cost, multi-diagnostic IC chip. Experimental results are available to support of the invention."
  2. Contact
    Taylor, Lee
  3. Service Provided by
    Office of Technology Transfer and Economic Development (OTTED)
  4. Website(s)
Provenance Metadata About This Resource Record
Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016