Licensing for laulimalides (microtubule stabilizing agents)

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1. Resource Description

   "A team of researchers at Utah State University and the University of Hawaii are conducting research on a new class of microtubule stabilizing agents, known as laulimalides. Laulimalide stimulates the polymerization of tubulin in the absence of polymerization promoters such as glycerol and GT. In cells, laulimalide induces dose-dependent reorganization of cellular micro-tubules, the formation of abnormal mitotic spindles and mitotic arrest, and is followed by initiation of apoptosis. The biological activities exhibited suggest a mechanism of action similar to paclitaxel (Taxol™). Application: cancer therapy."

2. Contact

   Taylor, Lee

3. Service Provided by

   Office of Technology Transfer and Economic Development (OTTED)

4. Website(s)

   http://www.otted.hawaii.edu/technology/00218/discovery-new-microtubule-stabilizing-agent-named-laulimalide