eagle-i University of Hawaii at ManoaUniversity of Hawaii at Manoa
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Patek Lab

eagle-i ID


Resource Type

  1. Laboratory


  1. Resource Description
    Our current work is focused on determining how expression of cancer-associated genes c-myc and p53 affects sensitivity to TNF and FasL induced programmed cell death in cell lines representing various stages on the pathway to cancer. We are also using our cell lineages to determine whether activation of caspase-2 plays a role in the differential sensitivity of cells to TNF- and FasL-mediated cytotoxicity. In addition, studies are underway to characterize TNF- and FasL-induced changes in mitochondrial membranes. This involves monitor the appearance of mitochondrial-associated proteins involved programmed cell death such as caspase-2, caspase-9, cytochrome c, and apoptosis Inducing factor.
  2. Contact
    Patek, Paul, Ph.D.
  3. PI
    Patek, Paul, Ph.D.
  4. Affiliation
    Department of Microbiology, University of Hawaii at Manoa
  5. Website(s)
Provenance Metadata About This Resource Record
Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016