eagle-i University of Hawaii at ManoaUniversity of Hawaii at Manoa
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Chang Lab

eagle-i ID

http://hawaii.eagle-i.net/i/0000012b-3598-e5f6-2f73-b43980000000

Resource Type

  1. Laboratory

Properties

  1. Resource Description
    "Malaria is a major cause of global morbidity and mortality in tropical countries and most notably among infants, young children and pregnant women in sub-Saharan Africa. Our long term goal is to develop a safe and effective blood stage vaccine directed against merozoite surface protein-1 (MSP1), a major coat protein of P. falciparum merozoites. This goal requires development of two essential components of a malaria vaccine, (i) the production of an optimally immunogenic antigen capable of inducing a protective immune response, and (ii) the identification of an immunostimulatory and non-toxic adjuvant formulation that may be combined with this antigen to generate protective immunity to falciparum malaria. Previous studies in this laboratory have focused on developing a baculovirus recombinant 42 kDa MSP1 C-terminal polypeptide which is highly immunogenic and induces protection in a non-human primate model of P. falciparum malaria. One of our current research objectives is to improve the protective immune response to a P. falciparum MSP1-based malaria vaccine by combining sequences located within MSP1 blocks 4, 16, and 17 to induce protective immune responses to multiple MSP1 epitopes. Our second research objective is to evaluate the ability of a series of well-defined immunomodulators to stimulate an immune response to MSP1 with in vitro and in vivo biological activities against P. falciparum blood stages. We hypothesize that a multi-epitope MSP1 antigen formulated with specific combinations of TLR (Toll-like receptor) and NOD (nucleotide-binding oligomerization domain-like receptor) agonists will be effective in inducing a protective immune response to P. falciparum infection."
  2. Contact
    Chang, Sandra, Ph.D.
  3. PI
    Chang, Sandra, Ph.D.
  4. Performs Technique
    Parasite culture
  5. Performs Technique
    Transcription profiling
  6. Performs Technique
    Genotyping assay
 
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Provenance Metadata About This Resource Record

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016