Allsopp Laboratory

eagle-i ID

Resource Type

Properties

1. Resource Description

   "Telomeres are essential genetic elements that cap the ends of chromosomes. The replication of telomeres in proliferating cells is accomplished by a specialized ribonucleic acid enzymatic complex called telomerase. I have been studying telomere shortening and cell aging as well as telomerase biology, especially regulation of telomerase, for over a decade. More recently, as a post doctoral fellow in Dr. Irving Weissman’s lab at Stanford University, I became interested in stem cell biology, especially the regulation of telomerase in stem cells. I joined the Institute for Biogenesis Research (IBR) in the summer of 2003 as an assistant professor, where I am at present. My current research interests at the IBR are still in the area of stem cell biology and telomere/telomerase biology, and also include research on factors controlling and effecting long-term stem cell survival. I am particularly interested in figuring out how telomerase is regulated in stem cells, and what role telomerase dysregulation may have during perinatal development. I am also interested in the role that a new gene, Sirt1, may play in different types of stem cells. Sirt1 is an NAD-dependent protein deacetylase that effects both cell survival and has been implicated as a transcriptional regulator of telomerase as well. Stem cells which I am particularly interested in include blood stem cells, germ line stem cells and neuronal stem cells."

2. Contact

   Allsopp, Richard, Ph.D.

3. PI

   Allsopp, Richard, Ph.D.

4. Affiliation

   Institute for Biogenesis Research, John A. Burns School of Medicine

5. Website(s)

   http://www.ibr.hawaii.edu/faculty/allsopp.html