Le Saux Lab

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1. Resource Description

   Calcification of cardiovascular tissues occurs in a variety of pathological conditions, including vascular injury, renal failure, diabetes mellitus, atherosclerosis, and aging. Mineralization is multifactorial and results from abormal changes in the balance between activators and inhibitors of calcification. We and others have established a link between ABCC6 and the chronic calcification of pseudoxanthoma elasticum (PXE) in human and the dystrophic cardiac calcification phenotype (DCC) in mice. ABCC6 is primarily expressed in liver and the kidneys but not in connective tissues. Therefore, we use various mice models to elucidate the characteristics of this novel mineralization inhibitor pathway.

2. Contact

   Le Saux, Oliver, Ph.D.

3. PI

   Le Saux, Oliver, Ph.D.

4. Affiliation

   Department of Cell and Molecular Biology, John A. Burns School of Medicine

5. Website(s)

   https://sites.google.com/site/ccrheart/research/le-saux-lab